I've only played through the first chapter due to school taking up most of my day, but here are a few thoughts.
It feels much more like a shooter than a survival horror game, much to my dismay.
Isaac feels more agile to me. Kind of like the difference in Shepard between Mass Effect and Mass Effect 2. But it still has the Resident Evil style movement, with the need to always turn Isaac the way you want to move.
It could be because I'm playing on Hard, but the enemies feel tougher than before.
Overall, not bad so far. I'm hoping the scare factor amps up, though...