2006 disagrees with you. U of L was a Rutgers field goal away from playing in the BCS Title game that year against Florida.
The player in your avatar played for a University that wasn't a major player until 1979 when it hired a pipe smoking rough neck coach that promised a NC in 5 years. It has been done before, can and will be done again. In today's age it just takes more money than it used to. Louisville has plenty of that.
That was in Miami, FL. Not Louisville, KY. The locations are completely different. And the high school talent levels are not even close to equal.